MP Lenza, L Egia-Mendikute, A Antoñana-Vildosola, CO Soares, H Coelho, F Corzana, A Bosch, P Manisha, JI Quintana, I Oyenarte, L Unione, MJ Moure, M Azkargorta, U Atxabal, K Sobczak, F Elortza, JD Sutherland, R Barrio, F. Marcelo**, J Jiménez-Barbero, A Palazon, J Ereño-Orbea “Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b.” Nat Commun. 14 1 (2023) 3496. doi: 10.1038/s41467-023-39119-8.
C. Oliveira Soares, A. S. Grosso, J. Ereño-Orbea, H. Coelho, F. Marcelo* “Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling”. Frontiers in Molecular Biosciences 8 (2021), Review, http://dx.doi. org/10.3389/fmolb.2021.727847.
C. D. L. Lima, H. Coelho, A. Gimeno, F. Trovão, A. Diniz, J. S. Dias, J. Jiménez-Barbero, F. Corzana, A. L. Carvalho, E. J. Cabrita, F. Marcelo* “Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins”. Chem. Eur. J. 27 29 (2021): 7951-7958. http://dx.doi.org/10.1002/chem.202100800.
Carbohydrates are key players in biological processes, involved in a myriad of molecular recognition events from protein folding, cell cell communication, bacterial and viral infections to fertilization. Cell-surface carbohydrates can differ considerably between cell lines and also between healthy and disease states.