Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide dendrimer cores, trigger selective inhibition of lysosomal β-glucocerebrosidase or α-mannosidase depending on valency and topology, offering new opportunities in multitargeted drug design. s/press release

Manuel González-Cuesta‡  a, David Goyard†  b, Eiji Nanba c, Katsumi Higaki c, José M. García Fernández  *d, Olivier Renaudet  *be and Carmen Ortiz Mellet  *a

Chem. Commun., 2019, 55, 12845-12848 DOI: 10.1039/C9CC06376E